Valacyclovir Hydrochloride

What it’s used for

Valacyclovir hydrochloride is a nucleoside analogue DNA polymerase inhibitor indicated for: Adult Patients (1. 1) • Cold Sores (Herpes Labialis) • Genital Herpes • Treatment in immunocompetent patients (initial or recurrent episode) • Suppression in immunocompetent or HIV-infected patients • Reduction of transmission • Herpes Zoster Pediatric Patients (1.

How to take it

2 DOSAGE AND ADMINISTRATION • Valacyclovir tablets may be given without regard to meals. Valacyclovir oral suspension (25 mg/mL or 50 mg/mL) may be prepared extemporaneously from 500 mg valacyclovir tablets for use in pediatric patients for whom a solid dosage form is not appropriate [see Dosage and Administration (2.

Important warnings

5 WARNINGS AND PRECAUTIONS • Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS): Has occurred in patients with advanced HIV disease and in allogenic bone marrow transplant and renal transplant patients receiving 8 grams per day of valacyclovir hydrochloride in clinical trials. Discontinue treatment if clinical symptoms and laboratory findings consistent with TTP/HUS occur.

Common side effects

The following serious adverse reactions are discussed in greater detail in other sections of the labeling: • Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome [see Warnings and Precautions (5. 1) ] .

Interactions

No clinically significant drug-drug or drug-food interactions with valacyclovir hydrochloride are known [see Clinical Pharmacology (12.

If pregnant or breastfeeding

8.

Forms & strengths

1000 MG Oral Tablet · 500 MG Oral Tablet · 250 MG Oral Tablet

Questions to ask your doctor or pharmacist

• Is this the right medicine for my condition, and how long should I take it?
• What side effects should I watch for, and which need urgent attention?
• Does this interact with my other medicines, supplements, or alcohol?
• What should I do if I miss a dose or take too much?