Trazodone Hydrochloride

Also sold as Trazodone Hydrochloride, TRAZODONE HYDROCHLORIDE

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: SUICIDAL THOUGHTS and BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors [see Warnings and Precautions ( 5.

4 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Trazodone is a selective serotonin reuptake inhibitor indicated for the treatment of major depressive disorder (MDD) ( 1 ). Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults.

How to take it

Starting dose: 150 mg in divided doses daily. May be increased by 50 mg per day every three to four days.

Important warnings

Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e. g.

Common side effects

Most common adverse reactions (incidence ≥ 5% and twice that of placebo) are: edema, blurred vision, syncope, drowsiness, fatigue, diarrhea, nasal congestion, weight loss ( 6 ). To report SUSPECTED ADVERSE REACTIONS, contact Zydus Pharmaceuticals (USA) Inc.

Interactions

Depressants: Trazodone may enhance effects of alcohol, barbiturates, or other CNS depressants ( 7 ).

If pregnant or breastfeeding

Forms & strengths

25 MG Oral Tablet · 75 MG Oral Tablet · 150 MG Oral Tablet · 300 MG Oral Tablet · 100 MG Oral Tablet · 50 MG Oral Tablet · 10 MG/ML Oral Solution · 100 MG Oral Capsule · 50 MG Oral Capsule

Questions to ask your doctor or pharmacist

Is this the right medicine for my condition, and how long should I take it?
What side effects should I watch for, and which need urgent attention?
Does this interact with my other medicines, supplements, or alcohol?
What should I do if I miss a dose or take too much?