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Sitagliptin And Metformin Hydrochloride

Also sold as ZITUVIMET, ZITUVIMET XR, Sitagliptin and Metformin hydrochloride, Sitagliptin and metformin hydrochloride, Sitagliptin and Metformin Hydrochloride

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: LACTIC ACIDOSIS WARNING: LACTIC ACIDOSIS See full prescribing information for complete boxed warning . Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias.
1 recall on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

1 INDICATIONS AND USAGE ZITUVIMET is a combination of sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin hydrochloride (HCl), a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. ( 1 ) Limitations of Use: ZITUVIMET is not recommended in patients with type 1 diabetes mellitus.

How to take it

Take ZITUVIMET orally twice daily with meals. ( 2.

Important warnings

Lactic Acidosis: See boxed warning . ( 5.

Common side effects

The following adverse reactions are also discussed elsewhere in the prescribing information: Lactic Acidosis [see Warnings and Precautions ( 5. 1 )] Pancreatitis [see Warnings and Precautions ( 5.

Interactions

Table 4 presents clinically significant drug interactions with ZITUVIMET: Table 4: Clinically Significant Drug Interactions with ZITUVIMET Carbonic Anhydrase Inhibitors Clinical Impact: Carbonic anhydrase inhibitors frequently cause a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.

If pregnant or breastfeeding

8.

Forms & strengths

100 MG Oral Tablet · 50 MG Oral Tablet · 25 MG Oral Tablet · 25 MG/ML Oral Solution

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?