Sacubitril And Valsartan

Also sold as ENTRESTO, Sacubitril and Valsartan

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: FETAL TOXICITY When pregnancy is detected, discontinue ENTRESTO as soon as possible (5. 1) Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (5.

What it’s used for

1 INDICATIONS AND USAGE ENTRESTO is a combination of sacubitril, a neprilisin inhibitor, and valsartan, an angiotensin II receptor blocker, and is indicated: to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits are most clearly evident in patients with left ventricular ejection fraction (LVEF) below normal.

How to take it

The recommended starting dosage for adults is 49 mg/51 mg orally twice daily. The target maintenance dose is 97 mg/103mg orally twice daily.

Important warnings

Observe for signs and symptoms of angioedema and hypotension. ( 5.

Common side effects

Clinically significant adverse reactions that appear in other sections of the labeling include: Angioedema [see Warnings and Precautions (5. 2)] Hypotension [see Warnings and Precautions (5.

Interactions

Avoid concomitant use with aliskiren in patients with estimated glomerular filtration rate (eGFR) less than 60.

If pregnant or breastfeeding

Forms & strengths

24 MG / 26 MG Oral Tablet · 49 MG / 51 MG Oral Tablet · 97 MG / 103 MG Oral Tablet

Questions to ask your doctor or pharmacist

Is this the right medicine for my condition, and how long should I take it?
What side effects should I watch for, and which need urgent attention?
Does this interact with my other medicines, supplements, or alcohol?
What should I do if I miss a dose or take too much?