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Pioglitazone Hydrochloride And Metformin Hydrochloride

Also sold as Pioglitazone Hydrochloride and Metformin Hydrochloride

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: CONGESTIVE HEART FAILURE and LACTIC ACIDOSIS Congestive Heart Failure Thiazolidinediones, including pioglitazone, which is a component of pioglitazone and metformin hydrochloride, cause or exacerbate congestive heart failure in some patients [see Warnings and Precautions (5. 1) ].
2 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Pioglitazone and metformin hydrochloride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Limitations of Use Pioglitazone and metformin hydrochloride tablets are not recommended to treat type 1 diabetes mellitus or diabetic ketoacidosis.

How to take it

Obtain liver tests before initiation. If abnormal, use caution when treating with pioglitazone and metformin hydrochloride, investigate the probable cause, treat (if possible), and follow appropriately.

Important warnings

Congestive Heart Failure: Fluid retention may occur and can exacerbate or lead to congestive heart failure. Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk.

Common side effects

The following serious adverse reactions are discussed elsewhere in the labeling: Congestive heart failure [see Boxed Warning , Warnings and Precautions (5. 1) ] Lactic acidosis [see Boxed Warning , Warnings and Precautions (5.

Interactions

Strong CYP2C8 inhibitors (e.

If pregnant or breastfeeding

8.

Forms & strengths

30 MG Oral Tablet · 45 MG Oral Tablet · 15 MG Oral Tablet

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?