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Nitrofurantoin (Monohydrate/Macrocrystals)

Also sold as Nitrofurantoin (monohydrate/macrocrystals), NITROFURANTOIN (monohydrate/macrocrystals), Nitrofurantoin

Medicine summary · from official FDA labels · Oct 19, 2026

5 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Nitrofurantoin (monohydrate/macrocrystals) is indicated only for the treatment of acute uncomplicated urinary tract infections (acute cystitis) caused by susceptible strains of Escherichia coli or Staphylococcus saprophyticus. Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses.

How to take it

Nitrofurantoin capsules (monohydrate/macrocrystals) should be taken with food. Adults and Pediatric Patients Over 12 Years One 100 mg capsule every 12 hours for seven days.

Important warnings

Pulmonary Reactions ACUTE, SUBACUTE, OR CHRONIC PULMONARY REACTIONS HAVE BEEN OBSERVED IN PATIENTS TREATED WITH NITROFURANTOIN. IF THESE REACTIONS OCCUR, NITROFURANTOIN (MONOHYDRATE/MACROCRYSTALS) SHOULD BE DISCONTINUED AND APPROPRIATE MEASURES TAKEN.

Common side effects

In clinical trials of nitrofurantoin (monohydrate/macrocrystals), the most frequent clinical adverse events that were reported as possibly or probably drug-related were nausea (8%), headache (6%), and flatulence (1. 5%).

Interactions

Drug Interactions Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption.

If pregnant or breastfeeding

Pregnancy Teratogenic Effects Several reproduction studies have been performed in rabbits and rats at doses up to six times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to nitrofurantoin.

Forms & strengths

25 MG / 75 MG Oral Capsule · 100 MG Oral Capsule · 100 MG Oral Tablet · 5 MG/ML Oral Suspension · 50 MG Oral Tablet · 25 MG Oral Capsule · 50 MG Oral Capsule · 10 MG/ML Oral Suspension

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?