Metformin Er 500 Mg

Also sold as Metformin

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: LACTIC ACIDOSIS Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain.

8 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Metformin hydrochloride extended-release tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. Metformin hydrochloride extended-release tablets are biguanide indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus.

How to take it

Recommended Dosage in Adults and Pediatric Patients Aged 10 Years and Older: • Swallow metformin hydrochloride extended-release tablets whole and never crush, cut or chew ( 2. 2 ) • Starting dosage: 500 mg orally once daily with the evening meal ( 2.

Important warnings

5 WARNINGS AND PRECAUTIONS N/A • Lactic Acidosis: See boxed warning. ( 5.

Common side effects

The following adverse reactions are also discussed elsewhere in the labeling: • Lactic Acidosis [see Boxed Warning and Warnings and Precautions (5. 1) ] • Vitamin B 12 Deficiency [see Warnings and Precautions (5.

Interactions

Table 2 presents clinically significant drug interactions with metformin hydrochloride extended-release tablets.

Forms & strengths

750 MG Oral Tablet · 1000 MG / 50 MG Oral Tablet · 500 MG / 50 MG Oral Tablet · 1000 MG Oral Tablet · 500 MG Oral Tablet · 850 MG Oral Tablet · 625 MG Oral Tablet · 100 MG/ML Oral Solution · 1000 MG / 2 MG Oral Tablet · 1000 MG / 4 MG Oral Tablet · 500 MG / 15 MG Oral Tablet · 500 MG / 1 MG Oral Tablet · 500 MG / 2 MG Oral Tablet · 500 MG / 4 MG Oral Tablet · 850 MG / 15 MG Oral Tablet

Questions to ask your doctor or pharmacist

Is this the right medicine for my condition, and how long should I take it?
What side effects should I watch for, and which need urgent attention?
Does this interact with my other medicines, supplements, or alcohol?
What should I do if I miss a dose or take too much?