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Lisinopril And Hydrochlorothiazide

Also sold as Lisinopril and Hydrochlorothiazide

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: FETAL TOXICITY See full prescribing information for complete boxed warning. When pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible.
8 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Lisinopril and hydrochlorothiazide tablets USP are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.

How to take it

Lisinopril monotherapy is an effective treatment of hypertension in once-daily doses of 10 mg to 80 mg, while hydrochlorothiazide monotherapy is effective in doses of 12. 5 mg per day to 50 mg per day.

Important warnings

Lisinopril Anaphylactoid and Possibly Related Reactions: Presumably because angiotensin-converting enzyme inhibitors affect the metabolism of eicosanoids and polypeptides, including endogenous bradykinin, patients receiving ACE inhibitors (including lisinopril and hydrochlorothiazide) may be subject to a variety of adverse reactions, some of them serious. Head and Neck Angioedema: Angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors, including lisinopril.

Common side effects

Lisinopril and hydrochlorothiazide have been evaluated for safety in 930 patients, including 100 patients treated for 50 weeks or more. In clinical trials with lisinopril and hydrochlorothiazide no adverse experiences peculiar to this combination drug have been observed.

Interactions

Drug Interactions Lisinopril Hypotension - Patients on Diuretic Therapy : Patients on diuretics, and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril.

If pregnant or breastfeeding

Nursing Mothers It is not known whether lisinopril is excreted in human milk.

Forms & strengths

1 MG/ML Oral Solution · 40 MG Oral Tablet · 30 MG Oral Tablet · 2.5 MG Oral Tablet · 5 MG Oral Tablet · 10 MG Oral Tablet · 20 MG Oral Tablet

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?