Evidence Health
← Back to the full page

Glyburide And Metformin Hydrochloride

Also sold as glyburide and metformin hydrochloride, Glyburide and Metformin Hydrochloride

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: LACTIC ACIDOSIS Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metforminassociated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain.

What it’s used for

Glyburide and metformin hydrochloride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Glyburide and metformin hydrochloride tablets are a combination of glyburide, a sulfonylurea, and metformin hydrochloride (HCl), a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

How to take it

Adult Dosage: Give glyburide and metformin hydrochloride tablets in divided doses, twice daily, with meals. (2.

Important warnings

Lactic Acidosis: See boxed warning. (5.

Common side effects

The following adverse reactions are also discussed elsewhere in the labeling: Lactic Acidosis [see Boxed Warning and Warnings and Precautions (5. 1) ] Hypoglycemia [see Warnings and Precautions (5.

Interactions

Table 3 presents clinically significant drug interactions with glyburide and metformin hydrochloride.

If pregnant or breastfeeding

8.

Forms & strengths

1.25 MG / 250 MG Oral Tablet · 2.5 MG / 500 MG Oral Tablet · 5 MG / 500 MG Oral Tablet · 1.25 MG Oral Tablet · 4.5 MG Oral Tablet · 2.5 MG Oral Tablet · 3 MG Oral Tablet · 5 MG Oral Tablet · 6 MG Oral Tablet · 1.5 MG Oral Tablet · 3.5 MG Oral Tablet · 1.75 MG Oral Tablet

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?