Glipizide And Metformin Hydrochloride

What it’s used for

Glipizide and metformin hydrochloride tablets USP are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

How to take it

General Considerations Dosage of glipizide and metformin hydrochloride tablets must be individualized on the basis of both effectiveness and tolerance while not exceeding the maximum recommended daily dose of 20 mg glipizide/2000 mg metformin. Glipizide and metformin hydrochloride tablets should be given with meals and should be initiated at a low dose, with gradual dose escalation as described below, in order to avoid hypoglycemia (largely due to glipizide), reduce GI side effects (largely due to metformin), and permit determination of the minimum effective dose for adequate control of blood glucose for the individual patient.

Important warnings

WARNINGS SPECIAL WARNING ON INCREASED RISK OF CARDIOVASCULAR MORTALITY The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. This warning is based on the study conducted by the University Group Diabetes Program (UGDP), a long-term prospective clinical trial designed to evaluate the effectiveness of glucose-lowering drugs in preventing or delaying vascular complications in patients with non-insulin-dependent diabetes.

Common side effects

Glipizide and Metformin Hydrochloride Tablets In a double-blind 24-week clinical trial involving glipizide and metformin hydrochloride tablets as initial therapy, a total of 172 patients received glipizide and metformin hydrochloride tablets, 2. 5 mg/250 mg, 173 received glipizide and metformin hydrochloride tablets, 2.

Interactions

Drug Interactions Glipizide and Metformin Hydrochloride Tablets Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control.

If pregnant or breastfeeding

Pregnancy Teratogenic Effects Recent information strongly suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities.

Forms & strengths

2.5 MG / 250 MG Oral Tablet · 2.5 MG / 500 MG Oral Tablet · 5 MG / 500 MG Oral Tablet · 15 MG Oral Tablet · 10 MG Oral Tablet · 5 MG Oral Tablet · 2.5 MG Oral Tablet

Questions to ask your doctor or pharmacist

• Is this the right medicine for my condition, and how long should I take it?
• What side effects should I watch for, and which need urgent attention?
• Does this interact with my other medicines, supplements, or alcohol?
• What should I do if I miss a dose or take too much?