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Estradiol

Also sold as Estradiol Vaginal, Estradiol

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA Estrogen-Alone Therapy Endometrial Cancer There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer.
8 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Estradiol Vaginal Cream, 0. 01% is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.

How to take it

Use of Estradiol Vaginal Cream, 0. 01% alone or in combination with a progestin, should be limited to the shortest duration consistent with treatment goals and risks for the individual woman.

Important warnings

See BOXED WARNINGS . Systemic absorption may occur with the use of Estradiol Vaginal Cream, 0.

Common side effects

See BOXED WARNINGS, WARNINGS and PRECAUTIONS . Systemic absorption may occur with the use of Estradiol Vaginal Cream, 0.

Interactions

D.

If pregnant or breastfeeding

F.

Forms & strengths

10 MG/ML / 50 MG/ML Injectable Suspension · 2 MG / 20 MG Oral Tablet · 0.5 MG / 0.1 MG Oral Tablet · 1 MG / 0.5 MG Oral Tablet · 0.5 MG Oral Tablet · 1 MG Oral Tablet · 2 MG Oral Tablet · 1.5 MG Oral Tablet · 1 MG / 100 MG Oral Capsule · 0.0006 MG Topical Gel · 2 MG / 1 MG Oral Tablet · 4 MG Oral Tablet · 2 MG / 0.7 MG Oral Tablet · 1 MG / 0.5 MG / 40 MG Oral Tablet · 0.5 MG / 100 MG Oral Capsule · 5 MG/ML Injectable Solution · 10 MG/ML Injectable Solution · 20 MG/ML Injectable Solution · 40 MG/ML Injectable Solution · 0.15 MG/ACTUAT Nasal Spray · 0.9 MG Oral Tablet · 0.45 MG Oral Tablet · 1.8 MG Oral Tablet · 3 MG Oral Tablet

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?