Duloxetine

Also sold as DULOXETINE HYDROCHLORIDE, Duloxetine

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older [see Warnings and Precautions (5.

8 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Duloxetine delayed-release capsules are indicated for the treatment of: Major depressive disorder in adults Generalized anxiety disorder in adults and pediatric patients 7 years of age and older Diabetic peripheral neuropathic pain in adults Fibromyalgia in adults Chronic musculoskeletal pain in adults Duloxetine delayed-release capsules are a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of the following conditions: Major depressive disorder (MDD) in adults (1) Generalized anxiety disorder (GAD) in adults and pediatric patients 7 years of age and older (1) Diabetic peripheral neuropathic pain (DPNP) in adults (1) Fibromyalgia (FM) in adults Chronic musculoskeletal pain in adults (1)

How to take it

Take duloxetine delayed-release capsules once daily, with or without food. Swallow whole; do not crush, chew, or open capsule (2.

Important warnings

Hepatotoxicity : Hepatic failure, sometimes fatal, has been reported. Discontinue duloxetine delayed-release capsule in patients who develop jaundice or other evidence of clinically significant liver dysfunction and should not be resumed unless another cause can be established.

Common side effects

The following serious adverse reactions are described below and elsewhere in the labeling: Suicidal Thoughts and Behaviors in Children, Adolescents, and Young Adults [see Boxed Warning and Warnings and Precautions (5. 1)] Hepatotoxicity [see Warnings and Precautions (5.

Interactions

Both CYP1A2 and CYP2D6 are responsible for duloxetine metabolism.

If pregnant or breastfeeding

Forms & strengths

80 MG Delayed Release Oral Capsule · 90 MG Delayed Release Oral Capsule · 120 MG Delayed Release Oral Capsule · 20 MG Delayed Release Oral Capsule · 30 MG Delayed Release Oral Capsule · 60 MG Delayed Release Oral Capsule · 40 MG Delayed Release Oral Capsule

Questions to ask your doctor or pharmacist

Is this the right medicine for my condition, and how long should I take it?
What side effects should I watch for, and which need urgent attention?
Does this interact with my other medicines, supplements, or alcohol?
What should I do if I miss a dose or take too much?