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Duloxetine Hydrochloride

Also sold as Duloxetine Delayed-Release, Duloxetine Hydrochloride, DULOXETINE DELAYED-RELEASE

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older [see Warnings and Precautions (5.
8 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Duloxetine Delayed-release Capsules is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for: • Major Depressive Disorder (MDD) ( 1. 1 ) • Generalized Anxiety Disorder (GAD) ( 1.

How to take it

Duloxetine Delayed-release Capsules should be swallowed whole and should not be chewed or crushed, nor should the capsule be opened and its contents sprinkled on food or mixed with liquids. All of these might affect the enteric coating.

Important warnings

5. WARNINGS AND PRECAUTIONS • Suicidality: Monitor for clinical worsening and suicide risk ( 5.

Common side effects

6. ADVERSE REACTIONS • Most common adverse reactions (≥5% and at least twice the incidence of placebo patients): nausea, dry mouth, somnolence, constipation, decreased appetite, and hyperhidrosis ( 6.

Interactions

Both CYP1A2 and CYP2D6 are responsible for duloxetine metabolism.

If pregnant or breastfeeding

8.

Forms & strengths

80 MG Delayed Release Oral Capsule · 90 MG Delayed Release Oral Capsule · 120 MG Delayed Release Oral Capsule · 20 MG Delayed Release Oral Capsule · 30 MG Delayed Release Oral Capsule · 60 MG Delayed Release Oral Capsule · 40 MG Delayed Release Oral Capsule

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?