Evidence Health
← Back to the full page

Diphenhydramine Hydrochloride

Also sold as Diphenhydramine, VICKS ZzzQuil NIGHTTIME SLEEP-AID Diphenhydramine HCl FREE OF, Good Neighbor Pharmacy Childrens Allergy, DIPHENHYDRAMINE HYDROCHLORIDE

Medicine summary · from official FDA labels · Oct 19, 2026

4 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Uses for the relief of occasional sleeplessness reduces time to fall asleep if you have difficulty falling asleep

How to take it

Directions take only one dose (30 mL) per day (24 hours) only use dose cup provided adults & children 12 yrs & over 30 mL at bedtime if needed or as directed by a doctor children under 12 yrs do not use

Important warnings

Warnings Do not use for children under 12 years of age with any other product containing diphenhydramine, even one used on skin

If pregnant or breastfeeding

If pregnant or breast-feeding, ask a health professional before use.

Forms & strengths

38 MG / 200 MG Oral Tablet · 25 MG / 200 MG Oral Capsule · 50 MG Oral Capsule · 25 MG Oral Tablet · 50 MG/ML Injectable Solution · 0.02 MG Topical Gel · 1.25 MG/ML Oral Solution · 10 MG/ML Topical Cream · 12.5 MG Chewable Tablet · 2.5 MG/ML Oral Solution · 25 MG Oral Capsule · 20 MG/ML Topical Cream · 25 MG / 10 MG Oral Tablet · 50 MG Oral Tablet · 2.5 MG/ML / 1 MG/ML Oral Solution · 20 MG/ML / 1 MG/ML Topical Cream · 25 MG Disintegrating Oral Tablet · 0.02 MG / 0.01 MG Topical Gel · 1.25 MG/ML / 0.5 MG/ML Oral Solution · 20 MG/ML / 10 MG/ML Topical Cream · 1.67 MG/ML Oral Solution · 0.5 MG/ML Injectable Solution · 1 MG/ML Injectable Solution · 2 MG/ML Oral Solution

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?