Diclofenac Sodium

Also sold as Diclofenac Sodium, ARTHRITIS PAIN RELIEVER, Diclofenac sodium, Arthritis Pain Reliever, Diclofenac Sodium Topical 1%

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS Cardiovascular Thrombotic Events Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction, and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use.

8 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Diclofenac sodium topical solution is indicated for the treatment of the pain of osteoarthritis of the knee(s). Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of the pain of osteoarthritis of the knee(s).

How to take it

Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. The recommended dose is 2 pump actuations on each painful knee, 2 times a day.

Important warnings

Hepatotoxicity : Inform patients of warning signs and symptoms of hepatotoxicity. Discontinue if abnormal liver tests persist or worsen or if clinical signs and symptoms of liver disease develop ( 5.

Common side effects

The following adverse reactions are discussed in greater detail in other sections of the labeling: Cardiovascular Thrombotic Events [ see Warnings and Precautions ( 5. 1 ) ] GI Bleeding, Ulceration and Perforation [ see Warnings and Precautions ( 5.

Interactions

See Table 3 for clinically significant drug interactions with diclofenac.

If pregnant or breastfeeding

Forms & strengths

10 MG/ML Topical Cream · 25 MG Delayed Release Oral Capsule · 50 MG Delayed Release Oral Capsule · 75 MG / 0.2 MG Delayed Release Oral Tablet · 18 MG Oral Capsule · 35 MG Oral Capsule · 20 MG/ML Topical Solution · 0.01 MG / 0.045 MG Topical Gel · 0.01 MG / 0.05 MG Topical Ointment · 0.01 MG / 0.05 MG Topical Gel · 75 MG Oral Tablet · 1 MG/ML Ophthalmic Solution · 0.01 MG Topical Gel · 0.03 MG Topical Gel · 25 MG Delayed Release Oral Tablet · 50 MG Delayed Release Oral Tablet · 75 MG Delayed Release Oral Tablet · 50 MG Oral Tablet · 0.25 MG/ML Oral Solution · 100 MG Rectal Suppository · 12.5 MG Rectal Suppository · 15 MG/ML Topical Solution · 25 MG Oral Tablet · 25 MG Rectal Suppository

Questions to ask your doctor or pharmacist

Is this the right medicine for my condition, and how long should I take it?
What side effects should I watch for, and which need urgent attention?
Does this interact with my other medicines, supplements, or alcohol?
What should I do if I miss a dose or take too much?