Dapagliflozin And Metformin Hydrochloride

Also sold as DAPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE, Dapagliflozin and Metformin Hydrochloride

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: LACTIC ACIDOSIS Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain.

1 recall on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Dapagliflozin and metformin HCl extended-release tablets are a combination of dapagliflozin and metformin hydrochloride (HCl) extended-release, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Dapagliflozin, when used as a component of dapagliflozin and metformin HCl extended-release tablets, is indicated in adults with type 2 diabetes mellitus to reduce the risk of: Sustained eGFR decline, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in patients with chronic kidney disease at risk of progression.

How to take it

Assess renal function prior to initiating and then as clinically indicated. ( 2.

Important warnings

Lactic Acidosis : See boxed warning. ( 5.

Common side effects

The following important adverse reactions are described below and elsewhere in the labeling: Lactic Acidosis [see Boxed Warning and Warnings and Precautions (5. 1) ] Diabetic Ketoacidosis in Patients with Type 1 Diabetes Mellitus and Other Ketoacidosis [see Warnings and Precautions (5.

Interactions

Table 6: Clinically Relevant Interactions with Dapagliflozin and Metformin Hydrochloride Extended-Release Carbonic Anhydrase Inhibitors Clinical Impact Topiramate or other carbonic anhydrase inhibitors (e.

If pregnant or breastfeeding

Forms & strengths

10 MG Oral Tablet · 5 MG Oral Tablet · 10 MG / 5 MG Oral Tablet · 5 MG / 5 MG Oral Tablet

Questions to ask your doctor or pharmacist

Is this the right medicine for my condition, and how long should I take it?
What side effects should I watch for, and which need urgent attention?
Does this interact with my other medicines, supplements, or alcohol?
What should I do if I miss a dose or take too much?