Clopidogrel

Also sold as Clopidogrel

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING:DIMINISHED ANTIPLATELET EFFECT IN PATIENTS WITH TWO LOSS-OF-FUNCTION ALLELES OF THE CYP2C19 GENE The effectiveness of clopidogrel results from its antiplatelet activity, which is dependent on its conversion to an active metabolite by the cytochrome P450 (CYP) system, principally CYP2C19 [ see Warnings and Precautions ( 5. 1 ), Clinical Pharmacology ( 12.

3 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Clopidogrel is a P2Y 12 platelet inhibitor indicated for: Acute coronary syndrome For patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)], clopidogrel tablets have been shown to reduce the rate of myocardial infarction (MI) and stroke. (1.

How to take it

Acute coronary syndrome ( 2. 1 ) Initiate clopidogrel tablets with a single 300 mg oral loading dose and then continue at 75 mg once daily.

Important warnings

5 WARNINGS AND PRECAUTIONS CYP2C19 inhibitors: Avoid concomitant use of omeprazole or esomeprazole. ( 5.

Common side effects

The following serious adverse reactions are discussed below and elsewhere in the labeling: Bleeding [see Warnings and Precautions (5. 2) ] Thrombotic thrombocytopenic purpura [see Warnings and Precautions (5.

Interactions

7 DRUG INTERACTIONS CYP2C19 inducers: Increases levels of clopidogrel active metabolite and increases platelet inhibition.

If pregnant or breastfeeding

Forms & strengths

75 MG Oral Tablet · 300 MG Oral Tablet

Questions to ask your doctor or pharmacist

Is this the right medicine for my condition, and how long should I take it?
What side effects should I watch for, and which need urgent attention?
Does this interact with my other medicines, supplements, or alcohol?
What should I do if I miss a dose or take too much?