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Bupropion Hydrochloride

Also sold as buPropion Hydrochloride XL, Bupropion Hydrochloride XL, Bupropion Hydrochloride, Bupropion Hydrochloride (XL), Bupropion Hydrochloride SR

Medicine summary · from official FDA labels · Oct 19, 2026

Serious warning: WARNING: SUICIDAL THOUGHTS AND BEHAVIORS SUICIDALITY AND ANTIDEPRESSANT DRUGS Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials. These trials did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in subjects aged 65 and older [see Warnings and Precautions (5.
8 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Bupropion hydrochloride extended-release tablet (XL) is an aminoketone antidepressant, indicated for: treatment of major depressive disorder (MDD) ( 1. 1 ) prevention of seasonal affective disorder (SAD) ( 1.

How to take it

General: Increase dose gradually to reduce seizure risk. ( 2.

Important warnings

Neuropsychiatric Adverse Events During Smoking Cessation: Postmarketing reports of serious or clinically significant neuropsychiatric adverse events have included changes in mood (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide. Observe patients attempting to quit smoking with bupropion hydrochloride extended-release tablets (XL) for the occurrence of such symptoms and instruct them to discontinue bupropion hydrochloride extended-release tablets (XL) and contact a healthcare provider if they experience such adverse events.

Common side effects

Most common adverse reactions are (incidence ≥5%; ≥2× placebo rate): dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash. ( 6.

Interactions

7 DRUG INTERACTIONS CYP2B6 inducers: Dose increase may be necessary if coadministered with CYP2B6 inducers (e.

If pregnant or breastfeeding

8.

Forms & strengths

105 MG / 45 MG Extended Release Oral Tablet · 105 MG / 30 MG Extended Release Oral Tablet · 100 MG Oral Tablet · 75 MG Oral Tablet

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?