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Acetaminophen And Diphenhydramine Hcl

Also sold as PANADOL PM

Medicine summary · from official FDA labels · Oct 19, 2026

8 recalls on record — a recall affects specific batches; check with your pharmacist.

What it’s used for

Uses temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness

How to take it

Directions do not take more than directed (see overdose warning) adults and children 12 years of age and over: take 2 caplets at bedtime, if needed, or as directed by a doctor do not give to children under 12 years of age

Important warnings

Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert: acetaminophen may cause severe skin reactions.

Common side effects

Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away.

If pregnant or breastfeeding

If pregnant or breast-feeding, ask a health professional before use.

Forms & strengths

250 MG / 125 MG Oral Tablet · 25 MG/ML / 20 MG/ML Oral Suspension · 325 MG / 97.5 MG Oral Tablet · 250 MG / 250 MG / 38 MG Oral Tablet · 160 MG / 230 MG / 33 MG Oral Tablet · 194 MG / 227 MG / 33 MG Oral Tablet · 115 MG / 210 MG / 16 MG / 65 MG Oral Tablet · 250 MG / 250 MG / 65 MG Oral Tablet · 110 MG / 162 MG / 32.4 MG / 152 MG Oral Tablet · 250 MG / 250 MG / 65 MG Oral Capsule · 325 MG / 25 MG / 5 MG Oral Tablet · 32 MG/ML / 1.25 MG/ML / 0.5 MG/ML Oral Solution · 325 MG / 12.5 MG Oral Tablet · 500 MG / 12.5 MG Oral Tablet · 500 MG / 50 MG Oral Tablet · 500 MG / 25 MG Oral Tablet · 33.3 MG/ML / 1.67 MG/ML Oral Solution · 325 MG / 50 MG Oral Tablet · 650 MG / 50 MG Oral Tablet · 65 MG/ML / 2 MG/ML / 2.5 MG/ML Oral Solution · 500 MG / 38 MG Oral Tablet · 500 MG / 25 MG Oral Capsule · 650 MG / 25 MG / 10 MG Oral Tablet · 325 MG / 12.5 MG / 5 MG Oral Tablet

Questions to ask your doctor or pharmacist

  • Is this the right medicine for my condition, and how long should I take it?
  • What side effects should I watch for, and which need urgent attention?
  • Does this interact with my other medicines, supplements, or alcohol?
  • What should I do if I miss a dose or take too much?